Joel Linden Selected Research

Purinergic P1 Receptors (Adenosine Receptor)

1/2022	Kinetic profiling and functional characterization of 8-phenylxanthine derivatives as A2B adenosine receptor antagonists.
1/2021	Clearance of apoptotic cells by lung alveolar macrophages prevents development of house dust mite-induced asthmatic lung inflammation.
12/2015	Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.
3/2015	The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors.
12/2014	Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.
8/2010	Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury.
5/2010	Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice.
1/2009	Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats.
11/2008	Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation.
10/2008	An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Joel Linden Research Topics

Disease

40	Inflammation (Inflammations) 01/2022 - 05/2002
26	Reperfusion Injury 01/2020 - 05/2002
23	Ischemia 03/2017 - 01/2002
13	Neoplasms (Cancer) 01/2022 - 05/2002
10	Sickle Cell Anemia (Hemoglobin S Disease) 09/2017 - 07/2009
9	Infections 01/2021 - 03/2001
9	Infarction (Infarctions) 03/2015 - 04/2005
7	Sepsis (Septicemia) 01/2021 - 01/2004
6	Pneumonia (Pneumonitis) 01/2021 - 04/2005
6	Myocardial Infarction 03/2015 - 04/2005
6	Spinal Cord Injuries (Spinal Cord Injury) 04/2008 - 08/2002
6	Spinal Cord Ischemia 04/2008 - 05/2002
5	Hypoxia (Hypoxemia) 09/2017 - 07/2009
5	Lung Injury 12/2010 - 03/2007
5	Edema (Dropsy) 08/2010 - 02/2004
4	Body Weight (Weight, Body) 12/2015 - 05/2005
4	Colitis 08/2014 - 07/2005
3	Asthma (Bronchial Asthma) 01/2022 - 09/2008
3	Neoplasm Metastasis (Metastasis) 01/2020 - 05/2013
3	Myocardial Ischemia (Ischemic Heart Diseases) 03/2015 - 07/2003
3	Fibrosis (Cirrhosis) 03/2013 - 01/2005
3	Weight Loss (Weight Reduction) 12/2012 - 02/2010
3	Endotoxemia 06/2010 - 05/2004
3	Pulmonary Edema 02/2010 - 05/2005
3	Ulcer 01/2009 - 02/2005
3	Necrosis 11/2006 - 07/2005
3	Paralysis (Palsy) 09/2002 - 05/2002
2	Pain (Aches) 01/2019 - 09/2017
2	Peripheral Arterial Disease 08/2017 - 03/2017
2	Melanoma (Melanoma, Malignant) 12/2014 - 12/2014
2	Enteritis 12/2012 - 01/2012
2	Diarrhea 12/2012 - 12/2012
2	Acute Kidney Injury (Acute Renal Failure) 11/2012 - 04/2006
2	Ileitis 01/2012 - 07/2005
2	Insulin Resistance 02/2011 - 01/2011
2	Bronchiolitis Obliterans 12/2010 - 10/2009
2	Parkinson Disease (Parkinson's Disease) 09/2010 - 03/2008
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2008 - 07/2005
2	Diabetic Nephropathies (Diabetic Nephropathy) 01/2008 - 04/2006
2	Wounds and Injuries (Trauma) 01/2006 - 09/2004
2	Coronary Occlusion 05/2005 - 07/2002
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2022
1	Glucose Intolerance 01/2022

Drug/Important Bio-Agent (IBA)

54	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 03/2001
37	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 09/2017 - 09/2002
29	ATL 146eIBA 12/2010 - 05/2002
25	Purinergic P1 Receptors (Adenosine Receptor)IBA 01/2022 - 09/2003
14	CytokinesIBA 12/2015 - 03/2001
10	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2010 - 05/2002
8	Peroxidase (Myeloperoxidase)IBA 08/2010 - 07/2002
7	ChemokinesIBA 01/2012 - 02/2004
6	EnzymesIBA 01/2021 - 05/2002
6	salicylhydroxamic acid (SHAM)IBA 02/2010 - 12/2004
5	LipopolysaccharidesIBA 12/2015 - 01/2004
5	ATL 313IBA 02/2010 - 04/2005
4	Adenosine A2B ReceptorIBA 01/2020 - 02/2011
4	EstersIBA 11/2006 - 05/2002
4	furanIBA 11/2006 - 05/2002
3	regadenoson FDA Link 01/2019 - 01/2012
3	Interleukin-6 (Interleukin 6)IBA 12/2012 - 01/2005
3	LigandsIBA 01/2012 - 05/2009
3	BuffersIBA 02/2010 - 11/2008
3	ImmunosorbentsIBA 03/2009 - 05/2002
3	Messenger RNA (mRNA)IBA 09/2008 - 01/2005
3	cyclohexanecarboxylic acidIBA 11/2006 - 05/2002
3	RolipramIBA 04/2005 - 03/2001
2	AllergensIBA 01/2021 - 01/2016
2	Vasodilator Agents (Vasodilators)IBA 08/2017 - 07/2005
2	Interleukin-12 (IL 12)IBA 01/2016 - 12/2014
2	Glucose (Dextrose)FDA LinkGeneric 12/2015 - 02/2011
2	Peptides (Polypeptides)IBA 03/2015 - 05/2009
2	CholesterolIBA 02/2015 - 07/2009
2	Interleukin-10 (Interleukin 10)IBA 12/2014 - 09/2006
2	AntigensIBA 12/2014 - 12/2014
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2012 - 05/2004
2	InterferonsIBA 09/2012 - 11/2006
2	P-SelectinIBA 12/2010 - 04/2005
2	Apolipoproteins E (ApoE)IBA 05/2010 - 07/2009
2	ApolipoproteinsIBA 05/2010 - 07/2009
2	triphenyltetrazoliumIBA 08/2009 - 12/2008
2	Interferon-gamma (Interferon, gamma)IBA 07/2009 - 11/2006
2	Evans Blue (Blue, Evans)FDA Link 03/2009 - 07/2007
2	Cyclic AMP (AMP, Cyclic)IBA 01/2009 - 09/2006
2	Proteins (Proteins, Gene)FDA Link 09/2008 - 03/2007
2	Transforming Growth Factor beta (TGF-beta)IBA 09/2006 - 01/2005
2	NF-kappa B (NF-kB)IBA 04/2006 - 11/2005
2	Phosphodiesterase InhibitorsIBA 01/2005 - 03/2001
1	Insulin (Novolin)FDA Link 01/2022
1	Adenosine DeaminaseIBA 01/2021
1	Neoplasm Antigens (Tumor Antigens)IBA 01/2020
1	Opioid Analgesics (Opioids)IBA 09/2017

Therapy/Procedure

9	Lung Transplantation 01/2020 - 11/2002
7	Therapeutics 01/2021 - 05/2004
3	Immunotherapy 01/2021 - 12/2014
3	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/2010 - 05/2005
2	Ligation 01/2021 - 03/2017
2	Thoracotomy 02/2010 - 12/2004
1	Punctures 01/2021
1	Length of Stay 09/2017
1	Ultrasonic Therapy 03/2017